The game is conducted with pitcher and batter cards constructed with statistical probabilities so they realistically reproduce the real-life performance of each player for the season represented. The gamer is placed in the role of the manager and/or general manager of a team and controls the batting order, the choice of a starting pitcher, game strategies (hit and run, steals, intentional walks, bunting, positioning of infielders, pinch hitters, defensive substitutions, pitching changes, etc.). If a full season is played, the game produces amazingly realistic statistics at the player, team, and league levels.

Every year, Strat-O-Matic releases new player card sets based on the previous baseball season, seasons past, and some "greats" collections.

(This is the most recent version of the game.)